The rising demand for the interconnectedness of electronic devices and data science has led to a greater need for seamless human-electronic device integration. However, the major challenge lies in the inability of conventional electronics to pick up reliable biological signals from the human body. This is due to fundamental mismatches such as incompatible surfaces (soft skin vs rigid sensors) and signal reading formats (physical vs digital systems). The emerging nano-bio interfaces have created new opportunities for developing advanced sensing technologies with unparalleled sensitivity and specificity. In this talk, I will present the development of conformal nano-bio interfaces that allow for the seamless integration of nanoelectronic interfaces into biological systems for sense digitalization with maintaining function even under deformed states. In addition, I will discuss the recent development of a biphasic, nano-dispersed (BIND) interface that can reliably connect soft, rigid, and encapsulation modules without the need for pastes. This interface was used to create stretchable devices for in vivo neuromodulation and on-skin electromyography. The modular integration improves signal quality and electrode performance, simplifying and accelerating the development of on-skin and implantable stretchable devices.