团队照片“多吃点鱼，聪明！”近日，浙江大学医学院和良渚实验室的张岩教授团队与山东大学孙金鹏教授、冯世庆教授和于晓教授团队合作，通过3年联合攻关，成功从原子分辨率水平解析了4种不同类型的脂肪酸和人工合成激动剂TUG891分别刺激Omega-3鱼油受体形成信号转导复合物的精细三维结构，详细阐述了Omega-3鱼油受体识别不同双键修饰的不饱和脂肪酸的模式，进而揭示了不同脂肪酸引发Omega-3鱼油受体产生下游特定信号谱图的机制。这一成果于北京时间3月3日，在线发表在国际顶级期刊《科学》。 AbstractIndividual free fatty acids (FAs) play important roles in metabolic homeostasis, many via engagement with more than 40 GPCRs. Searching for receptors to sense beneficial ω-3 FAs of fish oil enabled the identification of GPR120, involving with a spectrum of metabolic diseases. Here, we report six cryo-EM structures of GPR120 in complex with FA hormones or TUG891 and Gi or Giq trimers. Aromatic residues inside the GPR120 ligand pocket were responsible for recognizing different double-bond positions of these FAs and connect ligand recognition to distinct effector coupling. We also investigated synthetic ligand selectivity and the structural basis of missense single nucleotide polymorphisms. We reveal how GPR120 differentiates rigid double bonds and flexible single bonds and may facilitate rational drug design targeting to GPR120.▲A,Omega-3鱼油受体信号传导及相关功能的概述；B,不同饱和程度的脂肪酸和合成激动剂TUG891的化学结构。▲A-B, Omega-3鱼油受体-Gi/Giq冷冻电镜结构；C, 多种不同配体的电镜密度；D, Omega-3鱼油受体（绿色）的配体结合口袋与其他脂肪酸受体（黄色）配体结构口袋的比较。▲Omega-3鱼油受体中参与识别脂肪酸双键的芳香族残基分布和功能研究分道扬镳的秘密A,Omega-3鱼油受体信号传导及相关功能的概述；B,不同饱和程度的脂肪酸和合成激动剂TUG891的化学结构。https://www.science.org/doi/10.1126/science.add6220来源：文汇报、PaperRSS往期推荐1. 彻底解决癌症：癌症疫苗，方向在哪？What’s next for cancer vaccines2. 我国首部HPV预防专家共识出炉，所有女性不得不看！3. 多地学校停课、奥司他韦遭抢，甲流+新冠如何破？4. Immunity | 广谱抗beta冠状病毒抗体可以保护小鼠模型免受多种人类高致病性冠状病毒感染生命科学综合交流QQ群:681341860