讲座信息
讲座主题：From genetic associations to target genes, mechanisms, and medicine
日期：2023年10月17日（周二）晚20:00-21:30
主讲嘉宾介绍
Jian Yang
Jian Yang is a Professor of Statistical Genetics at the School of Life Sciences, Westlake University, China. He received his PhD in 2008 from Zhejiang University, China, before undertaking postdoctoral research at the QIMR Berghofer Medical Research Institute in Australia (2008-2011). He moved to The University of Queensland (UQ), Australia, as a Research Fellow in 2012 and was reappointed as a Senior Research Fellow and Group Leader in January 2014. He was promoted to be an Associate Professor in December 2014, and then a Professor in January 2017 at UQ. He joined Westlake University in 2020.
His primary research interests are focused on understanding the genomic variations among individuals within and between populations and the links of DNA variations and modifications to phenotypes and diseases.
He was the 2012 recipient of the Centenary Institute Lawrence Creative Prize, in recognition of his contribution to solving the ‘missing heritability’ paradox. He was awarded the Australian Academy of Science Ruth Stephens Gani Medal for distinguished research in human genetics (2015) and the Prime Minister’s Prize for Sciences - Frank Fenner Prize for Life Scientist of the Year (2017). He was named in the Clarivate Highly Cited Researchers in five consecutive years from 2018 to 2022. He has published a career total of >200 papers, which have received >86,000 citations (Google Scholar, Sep 2023).
报告摘要
Most human traits, including many physiological characteristics, behaviors, and susceptibilities to diseases and pathogen infections, are complex as they are influenced by a multitude of genetic and environmental factors. Genome-wide association studies (GWAS) have been instrumental in identifying genetic loci associated with these complex traits and diseases. However, the identification of target genes responsible for the GWAS signals remains a challenge, largely due to the complex linkage disequilibrium of common variants and the prevalence of GWAS signals in non-coding genomic regions. In this talk, I will introduce methods to integrate data from genetic association studies of molecular phenotypes and epigenomic studies into GWAS for prioritizing target genes from GWAS signals and inferring the corresponding genetic regulatory mechanisms. Additionally, I will discuss how this enhanced understanding can be harnessed for drug repurposing, offering new avenues for therapeutic interventions.
主持人介绍
倪挺
倪挺，男，1977年出生于江苏省，博士，教授，博士生导师。2000年获北京大学生命科学学院学士学位，2000-2006年硕博连读于北京大学生命科学学院。2007-2010年在美国杜克大学从事博士后研究。2010-2012年在美国国立卫生研究院(NIH)担任助理研究员。2012年起受聘为复旦大学生命科学学院教授。2022年起挂职内蒙古大学生命科学学院/生物医学研究院副院长。
倪教授在Nature、Science、Nature Methods、Science Advances、Nature Communications（2篇）、PNAS（2篇）、Genome Research（3篇）、Nucleic Acids Research（3篇）、Aging Cell（2篇）、Protein Cell等国际知名杂志发表50余篇SCI研究论文，成果被Nature Methods、Nature Reviews Genetics等评述。长期致力于mRNA加工成熟的机制及生物学意义研究，聚焦mRNA非编码区（内含子及3′非翻译区）在细胞衰老及癌变中的功能机制解析，建立了研究mRNA非编码区的系列方法，揭示了疾病相关点突变及多个重要RNA结合蛋白通过改变mRNA非编码区来调控细胞衰老的分子机制，提出了动态变化的mRNA非编码区调节细胞衰老的新观点，拓展了mRNA非编码区在衰老相关疾病中的生物学意义。主持国家973计划课题和国家重点研发计划课题各1项，主持国家基金委重大研究计划培育项目及集成项目各1项，主持国家基金委面上项目3项，参与国家973计划课题和国家重点研发计划课题各1项，是基金委创新群体骨干成员。担任中国老年学和老年医学学会老年病学分会衰老基础医学专家委员会副主任委员、上海市遗传学会副秘书长、中国环境诱变剂学会暴露组学与暴露科学专业委员会常务委员等。
主办单位
上海国际人类表型组研究院
Phenomics表型组学期刊
复旦大学人类表型组研究院
中国生物物理学会表型组学分会